Wuliang Zhang

Scientist at Orna Therapeutics

I am a scientist at Orna Therapeutics, investigating LNP-oRNA's physical and chemical properties using liquid chromatography-based techniques. Prior to joining Orna, I received my Ph.D. at Northwestern University, supervised by Chad Mirkin. My research focus was on designing tumor-targeting nanoparticles with high internalization rate into cancer cells, and with improved bioavailability and tumor accumulation. To this end, I incorporated active targeting and stealth effects into nanoparticles by coating tailored proteins onto their surfaces, and designed nanoparticles with a tumor-associated enzyme-cleavable surface protection layer. I also investigated the biological behaviors of liposomes whose surface is co-grafted with nucleic acids and hydrophilic polymers.

At Northwestern, I was also involved with the Advanced Degree Consulting Alliance, serving as the Co-President from 2019 to 2020.

Prior to this, I received my Bachelor's and Master's degrees from The University of Michigan in Ann Arbor, where I did research in Raoul Kopelman's research group.

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